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As well as a circular backbone, cyclotides contain a knotted arrangement of cross-linking disulfide bonds, making them remarkably stable. the discovery of cyclotides, the largest known family of circular proteins.In particular, his major achievements are: He moved to University of Queensland in 1995 to set up a new biomolecular NMR laboratory and is currently an Australian Research Council Laureate Fellow.ĭavid Craik has made discoveries of new classes of proteins, generated new knowledge on their structure and function, and used this information to design and chemically re-engineer new classes of protein-based drug leads and agricultural pest control agents. He was appointed Professor of Medicinal Chemistry and Head of School in 1988. He is an Honorary Professor of Jinan University, Guangzhou and has an Honorary Doctorate from Kalmar University in Sweden.ĭavid Craik obtained his PhD in organic chemistry from La Trobe University in Melbourne, Australia and undertook postdoctoral studies at Florida State and Syracuse Universities before taking up a lectureship at the Victorian College of Pharmacy in 1983. Hirschmann Award from the American Chemical Society (2011), Ramaciotti Medal for Excellence in Biomedical Research (2014), GlaxoSmithKline Award for Research Excellence (2014), the Vincent du Vigneaud Award from the American Peptide Society (2015) and the FAOBMB Award for Research Excellence (2015). He is a Fellow of the Australian Academy of Science and has received numerous awards for his research, including the Ralph F. He is author of over 600 scientific papers, including 6 in Nature/ Nature Communications/Nature Neoroscience/Nature Structural Biology/Nature Chemical Biology/Nature Chemistry, 1 in Science, 9 in PNAS and 8 in Angewandte Chemie. He heads a research team of 35 researchers whose current work focuses on applications of circular proteins, toxins and NMR in drug design. He discovered the cyclotide family of circular proteins and has characterized the structures of many animal toxins including conotoxins from cone snail venoms. David Craik is in the Division of Chemistry and Structural Biology at the Institute for Molecular Bioscience, The University of Queensland, Australia.